High Pressure Homogeniser

For Sale: Microfluidics M110EH Aseptic BioPharmaceutical Microfluidizer® Processor – GMP Pharmaceutical Production System

A rare opportunity to acquire a Microfluidics M110EH Aseptic BioPharmaceutical Microfluidizer® Processor, one of the industry's premier high-pressure homogenisation systems designed specifiy for sterile pharmaceutical manufacturing, biotechnology, and advanced formulation development. This highly specialised system is ideally suited for organisations involved in pharmaceutical manufacturing, biologics, vaccines, nanomedicine, liposomal formulations, biotechnology, and contract development and manufacturing (CDMOs). The specifications below are based on the manufacturer's brochure.

The M110EH is engineered for validated aseptic processing and delivers exceptional particle size reduction and process consistency. It is capable of producing high-quality nanoemulsions, nanosuspensions, liposomes, nanodispersions, and microencapsulated products, while also providing efficient cell disruption for yeast, bacterial, plant, and mammalian cells. Its proprietary Microfluidizer® technology produces highly uniform particle size distributions that improve product stability and bioavailability.

Designed to meet stringent pharmaceutical manufacturing requirements, the system features Steam-In-Place (SIP) sterilisation and Ultra-Clean-In-Place (UCIP) capability, eliminating the need for equipment disassembly between production runs. All product-contact surfaces are sanitary-grade, BPE compliant, electropolished where appropriate, and fully passivated, making the unit suitable for GMP production environments.

Performance specifications include operating pressures of up to 30,000 psi (2,068 bar) with product flow rates of 330 mL/min at maximum pressure or 450 mL/min at 25,000 psi, allowing efficient processing from pilot batches through to commercial production. The system can process batches as small as 1 litre while maintaining a low product hold-up volume of only 810 mL, reducing valuable product losses.

The processor is equipped with an advanced Siemens PLC control system with a 19-inch HMI, providing automated operation, secure electronic batch records, and 21 CFR Part 11 compliant data acquisition for regulated pharmaceutical manufacturing. Multiple RTD temperature sensors and PID-controlled cooling ensure precise thermal management, protecting temperature-sensitive formulations throughout processing.

Standard features include:

Pressure capability up to 30,000 psi (2,068 bar)
Pharmaceutical-grade product feed pump
Diamond Interaction Chamber
Ceramic Auxiliary Processing Module (APM)
Ceramic zirconia plunger for extended seal life
Automatic process controls
Stainless steel enclosure
Sanitary pressure transducers
CE compliant construction
Factory Acceptance Testing (FAT) documentation
IQ/OQ validation documentation
Support for Site Acceptance Testing (SAT)
Locking castors for mobility within production facilities.

This equipment represents an outstanding opportunity for pharmaceutical manufacturers, biotechnology companies, universities, research institutes, vaccine developers, and CDMOs seeking a validated production-scale Microfluidizer® without the lead times or capital investment associated with purchasing new equipment.

The M110EH is recognised worldwide as one of the benchmark systems for sterile high-pressure homogenisation and nanoparticle production, offering exceptional process reproducibility, scalability from laboratory development to commercial manufacture, and compliance with modern regulatory requirements.

Inspection welcome. Serious enquiries only.

Please contact us for further information, photographs, service history, and pricing.